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The perfect post-weight-loss finishing touch

Plenhyage Polynucleotide Injections

Plenhyage injections tighten and renew loose skin from within — available only at our Liverpool clinic. Ideal for post-weight-loss skin on the stomach, arms, and thighs.

  • Targets skin laxity after weight loss injections
  • Stimulates collagen naturally with advanced polynucleotide technology
  • No added volume — just firmer, stronger, smoother skin
  • Exclusively available at our Liverpool Street clinic
PricingHow Does It Work?How Many Sessions Do I Need?Why Choose UsFAQs

How much do Body Polynucleotides cost?

The cost of Body Polynucleotide treatment depends on the number of sessions required, the treatment area, and individual skin needs. Most patients need two – three polynucleotides treatments, spaced two to four weeks apart. Maintenance treatments are usually recommended every six to nine months.

1 x Area - Plenhyage XL Strong 2ml

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Single session · 10% off
Original price was: £399.00.Current price is: £359.10.Course of 3 · 20% off
Original price was: £1,197.00.Current price is: £957.60.
Only 319.20 per sessionCourse of 6 · 30% off
Original price was: £2,394.00.Current price is: £1,675.80.
Only 279.30 per session

From only £279.30 per session

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Whether you’ve lost weight through lifestyle changes or are using weight loss injections, loose skin can often remain — especially on the stomach, thighs or arms. Plenhyage injections use advanced polynucleotide technology to help your skin catch up with your body, offering a non-surgical solution to firm, tighten, and regenerate skin where it needs it most.

What Is Plenhyage?

Plenhyage is a next-generation polynucleotide-based injectable designed specifically for skin regeneration. It works beneath the surface, stimulating collagen, elastin and hydration — restoring structure to areas where the skin has thinned, sagged, or lost elasticity.

Unlike traditional dermal fillers, Plenhyage doesn’t add volume. Instead, it encourages your skin to repair itself from within, making it a powerful option for those experiencing post-weight-loss skin laxity.

Who Is This Treatment For?

Plenhyage is ideal for people who:

  • Are taking weight loss injections and have noticed loose, deflated or crepey skin
  • Have lost significant weight and are struggling with skin that hasn’t ‘bounced back’
  • Want to firm areas like the stomach, arms, thighs, or décolletage without surgery
  • Prefer natural-looking results over volume-based fillers

Whether you’re mid-transformation or maintaining your weight loss, Plenhyage offers the missing piece to help your skin match your efforts.

Treatment Areas

Plenhyage injections can be used on:

  • Abdomen and lower stomach
  • Arms (especially the underarm or ‘bingo wings’)
  • Inner and outer thighs
  • Knees
  • Décolletage
  • Neck and back of arms

These are common areas where skin laxity becomes more noticeable following weight loss or hormonal changes.

A Natural Match for Weight Loss Success

Weight loss can transform your body — but your skin often needs support to catch up. Plenhyage helps restore firmness and tone in a way that looks natural, not artificial. If you’re using weight loss injections or have reached your goal weight, this treatment is the next step toward a more confident, complete result.

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How Does It Work?

Plenhyage is made from highly purified polynucleotides, which act as bio-stimulators within the skin. Once injected, they:

  • Activate fibroblasts to produce new collagen and elastin
  • Improve tissue firmness, tone, and hydration
  • Reduce inflammation and oxidative stress that contribute to skin ageing
  • Support skin that’s been stretched or damaged due to weight fluctuations

Most clients see a visible improvement in skin texture and firmness over 2–4 weeks, with ongoing collagen production continuing for months after treatment.

How Many Sessions Do I Need?

We typically recommend a course of two treatments, spaced four weeks apart. A third may be advised depending on your level of skin laxity. Maintenance every six months helps preserve results long-term.

Is There Downtime?

There’s very little downtime with Plenhyage. You may experience mild redness or swelling at the injection sites, which typically settle within 48–72 hours. Small, raised bumps may appear temporarily — this is normal and will resolve on its own.

Why Choose Premier Laser Liverpool?

Our Liverpool clinic is the only location offering Plenhyage – delivered by trained and experienced aesthetic practitioners. We specialise in results-driven treatments for skin and body, offering safe, medical-grade care tailored to your journey.

Frequently Asked Questions

Does Plenhyage really work?

Yes, when administered correctly, Plenhyage can be highly effective. It stimulates your skin’s natural regeneration processes — including collagen production and tissue repair — leading to improved firmness, hydration and elasticity over time. Most clients see noticeable results within a few weeks of their second session.

What is the difference between Plenhyage and fillers?

Plenhyage is a regenerative treatment, not a volumising filler. While dermal fillers add volume or contour specific areas, Plenhyage encourages your skin to repair itself naturally. The result is firmer, healthier-looking skin without added fullness or structure.

How long does Plenhyage last?

Results typically last around 6 to 9 months, depending on your skin condition and lifestyle. Regular maintenance every 6 months is recommended to preserve the improvements in elasticity and skin tone.

Is Plenhyage a skin booster?

Yes — but it’s more than a typical skin booster. While many boosters focus solely on hydration, Plenhyage works deeper to stimulate collagen and elastin, making it ideal for those with more advanced concerns such as laxity, post-weight-loss skin changes, or ageing.

Are there side effects of Plenhyage?

Side effects are usually mild and temporary. You may experience slight swelling, redness or small bumps at the injection sites, which settle within 48 to 72 hours. As with any injectable treatment, there’s a small risk of bruising, but serious reactions are rare.

What is the best skin booster in the world?

There’s no single “best” skin booster, as it depends on your skin type and concerns. However, polynucleotide-based options like Plenhyage are gaining global recognition for their regenerative benefits — especially for clients needing firmer, more resilient skin without added volume.

Do skin booster injections really work?

Yes. Skin boosters improve hydration, elasticity, and texture by delivering targeted active ingredients beneath the skin’s surface. Plenhyage goes a step further by activating the body’s own collagen production, making it a longer-lasting, more restorative option.

Do polynucleotides tighten skin?

They do. Polynucleotides help stimulate collagen and elastin production, leading to gradual skin tightening and improved tone. They’re especially effective in areas where the skin has thinned or sagged, such as the stomach, arms, or inner thighs after weight loss.

What are the disadvantages of skin boosters?

Results are gradual, not instant, so patience is required. Multiple sessions are often needed, and while side effects are minimal, some clients may experience temporary swelling or bumps. It’s important to choose the right formulation and practitioner to ensure safe, effective treatment.

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